"No more cleats. I'm onto smoked meats, baby!" "Peace out, I'm out of here, later!" he says.
Wilfork was a five-time Pro Bowl selection and an All-Pro in 2012.
The 35 year-old Wilfork played his college ball at the University of Miami and was selected by the Patriots with the 21st overall pick in the 2004 NFL Draft.
Following the team's 2015 Super Bowl victory, Wilfork signed with the Houston Texans, for whom he played during the last two National Football League seasons.
Fans on Twitter were quick to thank Wilfork for his efforts on the field, and wish him luck in retirement.
The video also teased "Vince's Farewell Tailgate" set for "New England, September 7, 2017". The Patriots are at home to Kansas City Chiefs on the opening day of the season. He is one of the greatest players I've ever faced, having had the "pleasure" of looking across the line and seeing him on the opposite side of the ball, not once, but twice each season for a decade.
Wilfork finishes his career with 559 tackles, 26 passes defensed, 16 sacks, four forced fumbles and three interceptions.
In the fourth game of the 2013 season, in Atlanta, Wilfork suffered the only major injury of his career, a ruptured Achilles.
Wilfork's final game came in New England, a playoff loss in January.