Luis Suarez added Barca's fourth goal after a Messi pass, nine minutes after halftime and Denis Suarez made it 5-0 in the 74th minute and it should have been 6-0 after Paco Alcarer saw a late penalty saved after a foul on debutant Nelson Semedo.
If this was Gerard Deulofeu's audition to be Neymar's replacement at Barcelona, the former Everton winger did everything he could to convince the club he is ideal for the part in their 5-0 win over Chapecoense, on an emotional night at the Camp Nou.
Ruschel played the opening 35 minutes of the game, while the others watched on in Spain.
Follmann, who had part of his right leg amputated from injuries in the crash, was wearing a prosthetic leg when he took the kickoff along with Neto.
Ruschel was given the unenviable task of facing up to Messi on his return and despite the sentimentality of the occasion, Barca didn't let up once the game got underway.
Though still smarting from the sudden departure of Neymar, the Barça faithful could took heart from the energetic performance by Deulofeu, who was replaced by Denis Suarez at the start of the second half. After Sergio Busquets struck from long range, Deulofeu set up Messi for the third goal near the half-hour mark. Barcelona may have found a replacement for Neymar.
Barcelona eased to a 5-0 win, but the result mattered little to the players, coaches, or fans.
Chapecoense wasn't completely overrun and had a few spells of possession, but didn't trouble Barcelona's defense much.
19 of the 71 who tragically passed away were staff or players of the Brazilian club. At half-time with his first 45 minutes of the season complete after injury ruled him out of the summer tour to the United States he was replaced by Denis Suarez.
The final score didn't matter to either side. It won't heal wounds or end the heartache, but it was another step in the grieving process.